British scientists have discovered a gene in Drosophila that has a role similar to human aging genes. Drosophila may thus become a test subject for the study of human aging. Related papers were published in the recently published "senile cell" magazine.

Humans have a Werner syndrome. Patients are prematurely senescent before puberty. The root cause is a variation of a gene called WRN. Before scientists could only study how the gene worked in a single cell, they could not explore its developmental and overall effects.

The scientists discovered that fruit flies have genes similar to WRN. If this gene is damaged, the fruit fly will behave like a human with Werner syndrome. Specifically, its DNA becomes unstable and the chromosomes are often changed—the genes between different chromosomes are exchanged during recombination. This genomic instability in patients with Werner disease can lead to cancer. The patient will be extremely sensitive to a drug that treats cancer, and a very low dose of this drug will also kill fruit flies with similar genetic defects.

Researchers say that the principles of the human aging process are not fully understood. With the discovery of Drosophila senescence genes, the commonly used animals of the Drosophila test are expected to serve as research tools for the aging phenomenon.

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